Orgovyx – Relugolix


Oral: 120mg once daily
360mg (3 tablets) on day one, then 120mg (1 tablet) once daily thereafter


Oral: Administer at the same time each day, either with or without food. Swallow tablets whole, do not crush or chew.

Side Effects

Hypertension, fatigue, dizziness, joint pain, hot flashes, weight gain, diarrhea, constipation, and decreased sex drive.

Missed Dose

If it has been 12 hours or less since you missed your dose — take it as soon as possible.

If it has been more than 12 hours since you missed your dose — skip this dose. Take the next dose at your regular time.

Do not double the dose to catch up. If you miss more than one dose, talk to your doctor right away.

Reproductive Considerations

Male patients with female partners of reproductive potential should use effective contraception during treatment and for 2 weeks after the last Orgovyx dose.


CBC with diff and CMP (baseline, 3-4 weeks after initiation and every three months thereafter).

PSA every 3 months or as clinically indicated.

Monitor for QT prolongation.

Mechanism of Action

Orgovyx is a GnRH antagonist (gonadotropin-releasing hormone antagonist). It lowers the amount of testosterone flare. The flare causes levels to rise and can make certain symptoms, such as urinary problems or bone pain, worse in some patients.

In layman’s terms: This medication is ADT (androgen deprivation therapy) which helps lower the amount of testosterone the body makes. You are taking the med
to reduce the production of testosterone which as a result will slow down the growth and spread of cancer cells.


Store in a tightly-closed container at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Other Considerations

Be sure to let your other prescribers know that you are taking this medicine — this drug may interact with other drugs prescribed; you may be at higher risk for increased blood sugar levels and elevated triglyceride levels.